Karnim Capsules
Diabetes mellitus is a major lifestyle disease with varied etiology and is associated with a variety of irreversible complications. The modern management of Diabetes, inspite of newer developments remains unsatisfactory. The use of insulin is not indicated and in many cases is an effective due to insulin antagonistic and several other unknown mechanisms. The oral synthetic Hypoglycemic agents have been found to have limitations in therapeutic use, primarily because of their side effects.
A study of ancient Ayurvedic literature indicates that Prameha means Diabetes was fairly well conceived as a disease entity about 2500 years ago by the vedic physicians. Many indigenous drugs have been in popular use for the treatment of Diabetes since ancient times.
Karnim:
Karnim is indicated for patients with maturity onset diabetes mellitus. It is especially useful in case of Insulin resistance and Oral Antidiabetic failures. It can be used singly or in combination with other Antidiabetic drugs. Karnim is useful for obese Diabetes in which Sulfonyl urea are contraindicated. Dosage of Karnim is also convenient One capsule two times a day for freshly diagnosed no complicated diabetes, Secondly Karnim does not contain Shilajeet, which is advantage as compared to parallel brand compositions containing Shilajeet. Shilajeet is very hot in nature, In many patients whose physique is ‘Pitta prakruti’ may get giddiness, Vomiting sensation and acidity.
One capsule three times a day for cases of other oral hypoglycemia failure is the dose of Karnim. Karnim does not have side effects. While taking the treatment of karnim strict dietary control and regular exercise regimen must accompany. During Karnim therapy regular monitoring of blood sugar level is necessary. Karnim is a combination of proven Antidiabetic fortified with potent Immunomodular, Antihyperlipidemic. Hepatoprotective, Antistress, Expectorant, Anti-infiamrnatory of plant origin.
Karnim is a unique remedy as it acts on different sites in different ways to effectively control factors and pathways leading to Diabetes Mellitus. It controls causes as well as effects and condition. So Karnim is unique as compared to synthetic antidiabetic as they act on one site in one way only. It is safe and effective as a single agent supplement or Synthetic Anti diabetic drugs in uncontrolled Diabetes, Karnim helps overcome resistance to oral Hypoglycemic drugs. Karnim gives symptomatic relief of complaints like weakness, Giddiness, pain in legs, Bodyache, Polyuria.
Karnim consists of Karela also called as’Plant Insulin” The fruit contains a polypeptide made of 17 Amino acids out of which 16 are similar to crystalline insulin of bovine origin which are clinically found effective in primary Diabetics.
Karela decreases Glycogenolysis, Glycogenesis, retards protolysis and promotes protein synthesis. Thus M charantia exerts its charactive influence by normalising insulin deficiency status in controlled diabetes. Karela acts as a scavenger of superoxides and hydronyl radicals which are responsible for Diabetic conditions. Karela has a prophylactic role in a way that many diabetogenic chemicals like Allonan, sources of dietary Cyanide induce Diabetes due to irritant substances in food though damage to pancreatic beta cells via free radical generation cause Diabetic condition, which is avoided by free radical screening.
Neem (Azadirachta indica) stimulates insulin secretion by beta cells of islets of Langerhans of pancreas, Ginger (Zingiber officinale) stimulates beta cells to secrete Insulin. It consists of 6,8 and 10 Gingerols which cause inhibition of Na+ and K+ pump. Reduced K+ conductance cause membranes depolarisation and reflux of Ca++ ions through voltage sensitive Ca++ channels which ultimately stimulates insulin secretion by beta cells of pancreas. Thus Ginger increases Blood insulin level and decreases lipid level. Ginger acts as Digestive and increases Gastro-intestinal motility.
Tulsi (Ocimum sanctum) promotes uptake of Glucose by peripheral tissues by decreasing peripheral resistance to insulin. Tulsi has antistress activity due to which it effectively takes care of stress precipitated aggravation hyperglycemia. Tulsi has numerous pharmacological activities like Immunomodulator, Analgesic, Anti-inflammatory and Expectorant. Pure Commiphora mukul has Anti cholesteramic and Anti-hyperlipidemic action due to which it prevents Retinopathy, Neuropathy and Gangrenes which are secondary to atherosclerosis. Kutki (Picrorhiza kurroa) contains Kutkin possess hepatoprotective and corrective activity, Plant is a potent immunostimulant of both cell mediated and humoral immunity.
Where To Find It?
Best Deals And Pricing Available At karnim.com
Ingredients:
Karela (Momordica charantia)
Neem (Azadirachta indica)
Tulsi (Ocimum sanctum)
Kutki (Picrorrhiza kurroa)
Sounth (Zingiber officinale)
Shuddha Guggul (Commiphora mukul)
Pharmacology:
Karela (M. charantia)- Karela popularly known by scientists as plant insulin exerts it antidiabetic property by means of both pancreatic and extra pancreatic effects. The antidiabetic property of karela is due to two constituents of its fruit; a 17 amino acid polypeptide and charantin which is a mixture of two steroid glycoside. The ‘insulinornimetic’ property of karela is due to the 17 amino acid polypeptide which structurally resembles to a part of bovine insulin. The charantin bears a hypolglycemic property.
Neem (A. indica)- The active principle of neem, nimbidin is hypoglycemic in activity; it is also shown to stimulate the insulin secretion by activating the beta cells of islets of Langerhans in pancreas. Besides this primary activity, neem also corrects the immune system of body which usually deteriorates in diabetic condition.
Tulsi ( O. sanctum)- Tulsi promotes uptake of peripheral glucose most likely either by decreasing peripheral resistance to insulin or by any other action leading to promotion of insulin – receptor interaction. Tulsi is also known to possess antistress activity and thereby takes care of stress induced glucose intolerance and hyperglycemia. Secondly tulsi is shown to potentiate Action of exogenous insulin.
Kutki (P. karroa)- It acts as an immunomodulator by means of its irroid glycoside fraction which potentates the immune system. It is known to have a hepato-protective activity by means of restoring glycogen level. Sulfonyl urea like glibenclamide are known to precipitate cholestasis during diabetic therapy. Adjuvant therapy with Karnim which contain P. kurroa thus provide protection and prevent the toxic effects of allopathic antidiabetic drugs on liver.
Sounth (Z. officinale)- It has got a stimulatory effect on pancreas. This action is attributed to 6,8 &10 gingerols, which are assumed to cause inhibition of NA+ / K+ pump. This action depolarizes the cell membrane resulting in influx of Ca++ ions though voltage sensitive Ca++ channels which ultimately stimulates insulin secretion by beta cells of pancreas. Secondly it lowers the blood lipid level which is a common feature in diabetes due to excessive consumption of fats, which may onset atheroscleroses.
Purified Guggul (C. mukul)- One of the major complication in diabetes is elevated levels of very low-density lipoprotein (VLDL) in blood circulation. The VLDL is converted to more cholesterol rich LDL which causes onset of atherosclerosis in diabetic patients. The situation is more complicated in obese patients in whom the triglyceride levels are quite eleveted. C. mukul is a well known anti-cholesteremic and antihyperlipidemic agent which effectively prevents capillary thickening and subsequent pathological consequences in diabetes. This effect of C. mukul coupled with its fibrinolytic activity, also prevents retinopathy, neuropathy and gangerene which is secondary to atherosclerosis and precipitated when already narrowed blood vessels are blocked by blood clots (fibrin).
Indications:
To improve carbohydrate metabolism & managing blood sugar level.
Side Effects:
Karnim does not produce side effects such as nausea, vomiting, diarrhoea, rash and giddiness.
Special Precaution:
Strict dietary control and a regular exercise regimen must accompany Karnim therapy. Regular monitoring of blood sugar level is necessary.
Dosage:
Recently diagnosed patient, not taking oral hypoglycemic drugs- 1 to 2 Capsules three times a day, half an hour before meals.
Patients using Oral Hypoglycemic drugs and /or Insulin Injections- One capsule three times a day before meals.
Presentation: 100 Capsules Pack.
Where To Find It?
Best Deals And Pricing Available at karnim.com